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Description for Protein AVPR1B

arginine vasopressin receptor 1B
3 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene acts as receptor for arginine vasopressin. This receptor belongs to the subfamily of G-protein coupled receptors which includes AVPR1A, V2R and OXT receptors. Its activity is mediated by G proteins which stimulate a phosphatidylinositol-calcium second messenger system. The receptor is primarily located in the anterior pituitary, where it stimulates ACTH release. It is expressed at high levels in ACTH-secreting pituitary adenomas as well as in bronchial carcinoids responsible for the ectopic ACTH syndrome. A spliced antisense transcript of this gene has been reported but its function is not known. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04227
    KEGG - Pathway(s):
    hsa04020; hsa04080; hsa04270
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    V1BR; AVPR V1B; Vasopressin V3 receptor; AVPR V3; Antidiuretic hormone receptor 1b; AVPR3; VPR3; Vasopressin V1B receptor; Arginine vasopressin receptor 3; Antidiuretic hormone receptor 1B; Pituitary vasopressin receptor 3
    Approved Symbol:
    AVPR1B
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 1
    Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Desmopressin(db);
  • Terlipressin(db);
  • Vasopressin(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 7
    • Additional Identifiers:

    HPRD: 02600 Entrez Gene ID: 553 OMIM ID: 600264 Swissprot Accession: P47901;