Summary:
The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a gamma isoform of the regulatory subunit B56 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq] (PubMed Links)
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| Domains and Motifs:
NLS: Nuclear localization signal
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Gene Ontology:
KEGG - Enzyme ID(s):
KEGG - Orthology:
K11584
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KEGG - Pathway(s):
hsa04114; hsa04310
(The yellow boxes represents platelet proteins) |
Nomenclature / Alternative Names:
Serine/threonine protein phosphatase 2A, 56 kDa regulatory subunit, gamma isoform; PP2A, B subunit B` gamma isoform; PP2A, B subunit B56 gamma isoform; PP2A, B subunit PR61 gamma isoform; PP2A, B subunit R5 gamma isoform; PR61G; MGC23064; Protein phosphatase 2, regulatory subunit B (B56), gamma isoform; B56G; Gamma isoform of regulatory subunit B56, protein phosphatase 2A; Gamma isoform of regulatory subunit B56, protein phosphatase 2A isoform b; Gamma isoform of regulatory subunit B56, protein phosphatase 2A isoform c; Gamma isoform of regulatory subunit B56, protein phosphatase 2A isoform d; Gamma isoform of regulatory subunit B56, protein phosphatase 2A isoform a; KIAA0044
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Approved Symbol:
| (De-) Phosphorylations:
Phosphorylation Targets:
| Total phosphorylation targets: 0 |
| Human phosphorylation targets: 0; | Predicted platelet targets: 0 |
| Protein Characteristics:
|  Associated Drugs (DrugBank Accession):
(2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acid(db);
2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid(db)
Associated Genetic Diseases:
None Available
| Predicted Transmembrane Domains:
Isoform 4 : 0
Isoform 3 : 0
Isoform 2 : 0
Isoform 1 : 0
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