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Description for Protein PPP2R3A

protein phosphatase 2, regulatory subunit B'', alpha
9 total interacting proteins; 4 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes one of the regulatory subunits of the protein phosphatase 2. Protein phosphatase 2 (formerly named type 2A) is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2 holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B'' family. The B'' family has been further divided into subfamilies. The product of this gene belongs to the alpha subfamily of regulatory subunit B''. Alternative splicing results in multiple transcript variants encoding different isoforms. (PubMed Links)
Domains and Motifs:
  • EF: EF-hand, calcium binding motif
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K11583
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Protein phosphatase 2, regulatory subunit B``, alpha isoform 1; PR72; PR130; Serine/threonine protein phosphatase 2A 72/130 kDa regulatory subunit B; PP2A subunit B B double prime-PR72/PR130; PP2A subunit B B72/B130 isoforms; PP2A subunit B PR72/PR130 isoforms; PP2A subunit B R3 isoform; PPP2R3B; Protein phosphatase 2 (formerly 2A), regulatory subunit B` (PR 72), alpha isoform and (PR 130), beta isoform; Protein phosphatase 2, regulatory subunit B`, alpha isoform 2; PPP2R3
    Approved Symbol:
    PPP2R3A
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 1
    Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 09225 Entrez Gene ID: 5523 OMIM ID: 604944 Swissprot Accession: Q06190;