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Description for Protein PPP2R2B

protein phosphatase 2, regulatory subunit B, beta
6 total interacting proteins; 3 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(platelet: 10)
Summary:
The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a beta isoform of the regulatory subunit B55 subfamily. Defects in this gene cause autosomal dominant spinocerebellar ataxia 12 (SCA12), a disease caused by degeneration of the cerebellum, sometimes involving the brainstem and spinal cord, and in resulting in poor coordination of speech and body movements. Multiple alternatively spliced variants, which encode different isoforms, have been identified for this gene. The 5' UTR of some of these variants includes a CAG trinucleotide repeat sequence (7-28 copies) that can be expanded to 66-78 copies in cases of SCA12. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • WD40: WD40 repeats
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04354
    KEGG - Pathway(s):
    hsa04530; hsa05142
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    PP2APR55 beta; PP2AB55 beta; PP2AB beta; PR55 beta; Serine/threonine protein phosphatase 2A; Beta isoform of regulatory subunit B55, protein phosphatase 2 isoform d; EC 3.1.3.16; SCA12; MGC24888; Spinocerebellar ataxia 12; Beta isoform of regulatory subunit B55, protein phosphatase 2; Protein phosphatase 2 regulatory subunit B; PP2A, subunit B, PR55 beta isoform; PP2A, subunit B, B beta isoform; Serine/threonine protein phosphatase 2A, 55 kDa regulatory subunit B, beta isoform; Beta isoform of regulatory subunit B55, protein phosphatase 2 isoform a; Beta isoform of regulatory subunit B55, protein phosphatase 2 isoform b; Beta isoform of regulatory subunit B55, protein phosphatase 2 isoform c
    Approved Symbol:
    PPP2R2B
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Spinocerebellar ataxia 12(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 7 : 0
  • Isoform 6 : 0
  • Isoform 5 : 0
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 05059 Entrez Gene ID: 5521 OMIM ID: 604325 Swissprot Accession: A8MU22; Q00005;