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Description for Protein PPP2R1B

protein phosphatase 2, regulatory subunit A, beta
44 total interacting proteins; 30 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(platelet: 6)
Summary:
This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes a beta isoform of the constant regulatory subunit A. Mutations in this gene have been associated with some lung and colon cancers. Alternatively spliced transcript variants have been described. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • HEAT: HEAT repeat
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K03456
    KEGG - Pathway(s):
    hsa04114; hsa04310; hsa04350; hsa04530; hsa04730; hsa05142
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    MGC26454; Beta isoform of regulatory subunit A, protein phosphatase 2; PP2A, subunit A, PR65-beta; Serine/threonine protein phosphatase 2A, 65 kDa regulatory subunit A, beta; Protein phosphatase 2, structural/regulatory subunit A, beta; Beta isoform of regulatory subunit A, protein phosphatase 2 isoform a; Beta isoform of regulatory subunit A, protein phosphatase 2 isoform b
    Approved Symbol:
    PPP2R1B
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 4
    Human (de-) phosphorylation sites: 4; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Lung cancer(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 04384 Entrez Gene ID: 5519 OMIM ID: 603113 Swissprot Accession: P30154;