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Description for Protein PPP2R1A

protein phosphatase 2, regulatory subunit A, alpha
59 total interacting proteins; 37 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 9/0)
(membrane: 2; microparticles: 1; platelet: 6; secretome: 1)
Summary:
This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes an alpha isoform of the constant regulatory subunit A. Alternatively spliced transcript variants have been described. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • HEAT: HEAT repeat
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K03456
    KEGG - Pathway(s):
    hsa04114; hsa04310; hsa04350; hsa04530; hsa04730; hsa05142
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    PR65A; Protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha; Alpha isoform of regulatory subunit A, protein phosphatase 2; PP2A, subunit A, R1-alpha isoform; PP2A, subunit A, PR65-alpha isoform; Medium tumor antigen-associated 61 KDA protein
    Approved Symbol:
    PPP2R1A
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 2
    Human (de-) phosphorylation sites: 2; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • (2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acid(db);
  • 2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 16184 Entrez Gene ID: 5518 OMIM ID: 605983 Swissprot Accession: A8K7B7; P30153;