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Description for Protein DARS2

aspartyl-tRNA synthetase 2, mitochondrial
2 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene belongs to the class-II aminoacyl-tRNA synthetase family. It is a mitochondrial enzyme that specifically aminoacylates aspartyl-tRNA. Mutations in this gene are associated with leukoencephalopathy with brainstem and spinal cord involvement and lactate elevation (LBSL). [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
6.1.1.12
KEGG - Orthology:
K01876
KEGG - Pathway(s):
hsa00970
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
FLJ10514; ASPRS; ASPRS. LBSL; RP3-383J4.2; Aspartate tRNA ligase 2, mitochondrial; Aspartyl-tRNA synthetase, mitochondrial [Precursor]; EC 6.1.1.12; Aspartate--tRNA ligase; AspRS; Aspartyl-tRNA synthetase 2
Approved Symbol:
DARS2
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 2
Human (de-) phosphorylation sites: 2; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • L-Aspartic Acid(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 07677 Entrez Gene ID: 55157 OMIM ID: 610956 Swissprot Accession: Q6PI48;