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Description for Protein PPP2CA

protein phosphatase 2, catalytic subunit, alpha isozyme
97 total interacting proteins; 53 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 2/0)
(platelet: 1; secretome: 2)
Summary:
This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes an alpha isoform of the catalytic subunit. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • PP2A: Protein phosphatase 2A homologues, catalytic domain.
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.1.3.16
    KEGG - Orthology:
    K04382
    KEGG - Pathway(s):
    hsa04114; hsa04310; hsa04350; hsa04530; hsa04730; hsa05142
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    RP-C; PP2CA; PP2A-alpha; Replication protein C; Serine/threonine protein phosphatase 2A, catalytic subunit, alpha isoform
    Approved Symbol:
    PPP2CA
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 1
    Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • (2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acid(db);
  • 2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid(db);
  • Vitamin E(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 08912 Entrez Gene ID: 5515 OMIM ID: 176915 Swissprot Accession: P67775; B3KUN1;