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Description for Protein PPP1R8

protein phosphatase 1, regulatory (inhibitor) subunit 8
19 total interacting proteins; 13 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene, through alternative splicing, encodes three different isoforms. Two of the protein isoforms encoded by this gene are specific inhibitors of type 1 serine/threonine protein phosphatases and can bind but not cleave RNA. The third protein isoform lacks the phosphatase inhibitory function but is a single-strand endoribonuclease comparable to RNase E of E. coli. This isoform requires magnesium for its function and cleaves specific sites in A+U-rich regions of RNA. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • FHA: Forkhead associated domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.1.4.-
    KEGG - Orthology:
    K13216
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Nuclear inhibitor of protein phosphatase 1; Activator of RNA decay; ARD1; Protein phosphatase 1, regulatory subunit 8; PRO2047; Nuclear subunit of PP-1; EC 3.1.4.-; Protein phosphatase 1 regulatory inhibitor subunit 8 isoform beta/delta; Protein phosphatase 1 regulatory inhibitor subunit 8 isoform gamma; Protein phosphatase 1 regulatory inhibitor subunit 8 isoform alpha
    Approved Symbol:
    PPP1R8
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 20
    Human (de-) phosphorylation sites: 20; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 04028 Entrez Gene ID: 5511 OMIM ID: 602636 Swissprot Accession: Q12972; Q6ICT4; Q5TEJ4;