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Description for Protein ATG16L1

ATG16 autophagy related 16-like 1 (S. cerevisiae)
13 total interacting proteins; 8 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene is part of a large protein complex that is necessary for autophagy, the major process by which intracellular components are targeted to lysosomes for degradation. Defects in this gene are a cause of susceptibility to inflammatory bowel disease type 10 (IBD10). Several transcript variants encoding different isoforms have been found for this gene. (PubMed Links)
Domains and Motifs:
  • WD40: WD40 repeats
  • CC: Coiled Coil
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    None Available
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    APG16 autophagy 16-like isoform 3; APG16 autophagy 16-like; WDR30; FLJ00045; FLJ10035; FLJ10828; FLJ22677; APG16L beta; APG16 autophagy 16-like isoform 2; APG16 autophagy 16-like isoform 1
    Approved Symbol:
    ATG16L1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 12
    Human (de-) phosphorylation sites: 12; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 16498 Entrez Gene ID: 55054 OMIM ID: 610767 Swissprot Accession: Q676U5; Q17RG0;