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Description for Protein PPP1CB

protein phosphatase 1, catalytic subunit, beta isozyme
22 total interacting proteins; 10 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 6/2)
(platelet: 13; secretome: 1; undefined: 1)
Summary:
The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Mouse studies suggest that PP1 functions as a suppressor of learning and memory. Two alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • PP2A: Protein phosphatase 2A homologues, catalytic domain.
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.1.3.16
    KEGG - Orthology:
    K06269
    KEGG - Pathway(s):
    hsa04114; hsa04270; hsa04510; hsa04720; hsa04810; hsa04910
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Protein phosphatase 1, catalytic subunit, beta isoform 1; Protein phosphatase 1 beta; PP 1B; PPP1CD; MGC3672; Protein phosphatase 1 delta; Protein phosphatase 1 catalytic subunit delta; Serine/threonine protein phosphatase PP1 beta catalytic subunit; EC 3.1.3.16
    Approved Symbol:
    PPP1CB
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 6
    Human (de-) phosphorylation sites: 6; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 11792 Entrez Gene ID: 5500 OMIM ID: 600590 Swissprot Accession: P62140;