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Description for Protein ACPP

acid phosphatase, prostate
3 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(platelet: 3)
Summary:
This gene encodes an enzyme that catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is synthesized under androgen regulation and is secreted by the epithelial cells of the prostate gland. An alternatively spliced transcript variant encoding a longer isoform has been found for this gene. This isoform contains a transmembrane domain and is localized in the plasma membrane-endosomal-lysosomal pathway. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.1.3.2
    KEGG - Orthology:
    K01078
    KEGG - Pathway(s):
    hsa00740
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    PAP; PACP; Phosphatase prostate specific acid
    Approved Symbol:
    ACPP
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Alpha-Benzyl-Aminobenzyl-Phosphonic Acid(db);
  • Alpha-D-Mannose(db);
  • Fucose(db);
  • N-Propyl-Tartramic Acid(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 2
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 01378 Entrez Gene ID: 55 OMIM ID: 171790 Swissprot Accession: P15309;