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Description for Protein PPP1CA

protein phosphatase 1, catalytic subunit, alpha isozyme
92 total interacting proteins; 36 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 8/1)
(membrane: 1; phosphoproteome: 1; platelet: 8; secretome: 1; undefined: 1)
Summary:
The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Increased PP1 activity has been observed in the end stage of heart failure. Studies in both human and mice suggest that PP1 is an important regulator of cardiac function. Mouse studies also suggest that PP1 functions as a suppressor of learning and memory. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • PP2A: Protein phosphatase 2A homologues, catalytic domain.
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.1.3.16
    KEGG - Orthology:
    K06269
    KEGG - Pathway(s):
    hsa04114; hsa04270; hsa04510; hsa04720; hsa04810; hsa04910
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    PP-1A; PPP1A; MGC1674; MGC15877; Serine/threonine protein phosphatase PP1-alpha catalytic subunit; EC 3.1.3.16; Protein phosphatase 1, catalytic subunit, alpha isoform 3; Protein phosphatase 1, catalytic subunit, alpha isoform 1; Protein phosphatase 1, catalytic subunit, alpha isoform 2
    Approved Symbol:
    PPP1CA
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 5
    Human (de-) phosphorylation sites: 5; Platelet phosphorylation sites: 3
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • 2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 15942 Entrez Gene ID: 5499 OMIM ID: 176875 Swissprot Accession: P62136; Q07161; A6NNR3;