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Description for Protein PPM1G

protein phosphatase, Mg2+/Mn2+ dependent, 1G
7 total interacting proteins;
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(platelet: 1)
Summary:
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase is found to be responsible for the dephosphorylation of Pre-mRNA splicing factors, which is important for the formation of functional spliceosome. Studies of a similar gene in mice suggested a role of this phosphatase in regulating cell cycle progression. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • PP2C: Serine/threonine phosphatases, family 2C, catalytic domain
  • CC: Coiled Coil
  • PA2c: Phospholipase A2
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.1.3.16
    KEGG - Orthology:
    K01090
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    PPP2CG; MGC1675; MGC2870; Protein phosphatase 1G; PP2C gamma; Protein phosphatase 2, catalytic subunit, gamma; EC 3.1.3.16; Protein phosphatase 2C gamma; PP2CG; Protein phosphatase 1C; PPM1C
    Approved Symbol:
    PPM1G
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 8
    Human (de-) phosphorylation sites: 8; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 09237 Entrez Gene ID: 5496 OMIM ID: 605119 Swissprot Accession: Q6IAU5; O15355;