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Description for Protein PPM1B

protein phosphatase, Mg2+/Mn2+ dependent, 1B
18 total interacting proteins; 17 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/1)
(platelet: 12)
Summary:
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase has been shown to dephosphorylate cyclin-dependent kinases (CDKs), and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to cause cell-growth arrest or cell death. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional transcript variants have been described, but currently do not represent full-length sequences. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • PP2C: Serine/threonine phosphatases, family 2C, catalytic domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.1.3.16
    KEGG - Orthology:
    K04461
    KEGG - Pathway(s):
    hsa04010
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Protein phosphatase magnesium dependent 1 beta isoform; PP2CBETA; PP2CB; Protein phosphatase 2C-like protein; Protein phosphatase 1B (formerly 2C), magnesium-dependent, beta isoform; MGC21657; PPC2BETAX; EC 3.1.3.16; Protein phosphatase 1B isoform 1; Protein phosphatase 1B isoform 2; Protein phosphatase 1B isoform 5; Protein phosphatase 1B isoform 4; Protein phosphatase 1B isoform 3
    Approved Symbol:
    PPM1B
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 5 : 0
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 04796 Entrez Gene ID: 5495 OMIM ID: 603770 Swissprot Accession: Q4J6C2; O75688; Q4J6C1;