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Description for Protein NSUN2

NOP2/Sun domain family, member 2
4 total interacting proteins;
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
Maturation of cytoplasmic tRNAs includes splicing of introns, which are located 1 nucleotide 3-prime from the anticodon in all intron-containing tRNA genes. In tRNA-leu(CAA), the first position of the anticodon, C34, is converted to 5-methylcytosine, a modification necessary to stabilize the anticodon-codon pairing and correctly translate the mRNA. NSUN2 encodes a methyltransferase that catalyzes the intron-dependent formation of 5-methylcytosine at C34 of tRNA-leu(CAA) (Brzezicha et al., 2006 [PubMed 17071714]).[supplied by OMIM] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
None Available
KEGG - Orthology:
None Available
KEGG - Pathway(s):
None Available
Nomenclature / Alternative Names:
5-methycytoisine methyltransferase; SAKI; MISU; NOL1/NOP2/Sun domain family 2; tRNA methyltransferase 4; Myc-induced SUN-domain-containing; tRNA (cytosine-5-)-methyltransferase NSUN2; EC 2.1.1.29; Substrate of AIM1/Aurora kinase B; hTrm4; TRM4
Approved Symbol:
NSUN2
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 13
Human (de-) phosphorylation sites: 13; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

None Available

Associated Genetic Diseases:

None Available
Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 08620 Entrez Gene ID: 54888 OMIM ID: 610916 Swissprot Accession: Q08J23; B3KP09;