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Description for Protein TRPM7

transient receptor potential cation channel, subfamily M, member 7
10 total interacting proteins; 8 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/1)
(platelet: 2)
Summary:
The protein encoded by this gene is both an ion channel and a serine/threonine protein kinase. The kinase activity is essential for the ion channel function, which serves to increase intracellular calcium levels and to help regulate magnesium ion homeostasis. Defects in this gene are a cause of amyotrophic lateral sclerosis-parkinsonism/dementia complex of Guam. (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
  • Alpha_kinase: Alpha-kinase family
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.11.1
    KEGG - Orthology:
    K04982
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    LTRPC ion channel family member 7; Transient receptor potential melastatin 7; CHAK; CHAK1; LTRPC7; FLJ20117; TRP PLIK; Long transient receptor potential channel 7; Transient receptor potential phospholipase C interating kinase; Channel kinase 1
    Approved Symbol:
    TRPM7
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 49
    Human (de-) phosphorylation sites: 49; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 3
    Human phosphorylation targets: 3; Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • 1,4-Dithiothreitol(db);
  • Adenosine-5'-Diphosphate(db);
  • Phosphoaminophosphonic Acid-Adenylate Ester(db)

    Associated Genetic Diseases:

  • Amyotrophic lateral sclerosis-Parkinsonism/dementia complex 1, susceptibility to(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 6
    • Additional Identifiers:

    HPRD: 10418 Entrez Gene ID: 54822 OMIM ID: 605692 Swissprot Accession: Q96QT4;