Search

Search for a specific protein in the Platelet Interactome


(Example: vasp)

 

Advanced Search

Get detailed protein information focusing on various characteristics and extract interaction networks

 

Legend

 

About

Go Back

Description for Protein PPIB

peptidylprolyl isomerase B (cyclophilin B)
11 total interacting proteins; 7 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 8/1)
(alpha granules: 1; membrane: 1; microparticles: 1; platelet: 4; secretome: 1; undefined: 1)
Summary:
The protein encoded by this gene is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression. Variants have been identified in this protein that give rise to recessive forms of osteogenesis imperfecta. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    5.2.1.8
    KEGG - Orthology:
    K03768
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Peptidyl prolyl cis-trans isomerase B; PPIase; Rotamase; Cyclophilin B; CYPB; S cyclophilin; SCYLP; CYP-S1
    Approved Symbol:
    PPIB
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 2
    Human (de-) phosphorylation sites: 2; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • 1,4-Dithiothreitol(db);
  • L-Proline(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 00458 Entrez Gene ID: 5479 OMIM ID: 123841 Swissprot Accession: P23284;