 Platelet Evidence
(proteome studies/others : 10/3)
(alpha granules: 1; membrane: 1; microparticles: 1; platelet: 9; undefined: 2) |
Summary:
This gene encodes a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. The encoded protein is a cyclosporin binding-protein and may play a role in cyclosporin A-mediated immunosuppression. The protein can also interact with several HIV proteins, including p55 gag, Vpr, and capsid protein, and has been shown to be necessary for the formation of infectious HIV virions. Multiple pseudogenes that map to different chromosomes have been reported. [provided by RefSeq] (PubMed Links)
|
| Domains and Motifs:
Gene Ontology:
KEGG - Enzyme ID(s):
KEGG - Orthology:
K03767
|
KEGG - Pathway(s):
None Available
|
Nomenclature / Alternative Names:
Peptidyl prolyl cis-trans isomerase A; Peptidyl-prolyl isomerase A; Cyclosporin A binding protein; CYPA; CYPH; PPIase; Rotamase
|
Approved Symbol:
| (De-) Phosphorylations:
Phosphorylation Targets:
| Total phosphorylation targets: 0 |
| Human phosphorylation targets: 0; | Predicted platelet targets: 0 |
| Protein Characteristics:
|  Associated Drugs (DrugBank Accession):
(3r)-1-Acetyl-3-Methylpiperidine(db);
(3s,6s,9r,10r,11s,12s,13e,15e,18s,21s)-18-{(1e,3e,7s,8s)-9-[(2s,3r,4s,5s,6r,9s,11s)-9-Ethyl-4-Hydroxy-3,5,11-Trimethyl-8-Oxo-1-Oxa-7-Azaspiro[5.5]Undec-2-Yl]-8-Hydroxy-1,7-Dimethylnona-1,3-Dienyl}-10,12-Dihydroxy-3-(3-Hydroxybenzyl)-6-Isopropyl-11-Methyl-(db);
Cyclosporine(db);
Ethyl Oxo(Piperidin-1-Yl)Acetate(db);
L-Proline(db)
Associated Genetic Diseases:
None Available
| Predicted Transmembrane Domains:
Isoform 3 : 0
Isoform 2 : 0
Isoform 1 : 0
|
| |
|
