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Description for Protein PCSK4

proprotein convertase subtilisin/kexin type 4
1 total interacting proteins;
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(secretome: 1)
Summary:
Proprotein convertases, including PCSK4, are calcium-dependent serine proteases related to bacterial subtilisins and to yeast kexin. These enzymes process precursor proteins to their active forms by selective cleavage of the polypeptide at sites following paired basic amino acids. In mammals, this family comprises PC1 (MIM 162150), PC2 (MIM 162151), PC4, PC5 (MIM 600488), furin (FUR; MIM 136950), and PACE4 (MIM 167405). Substrates for these enzymes range from prohormones to precursors for growth factors to cell surface receptors and viral surface glycoproteins (Cao et al., 2001 [PubMed 11776387]).[supplied by OMIM] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • FU: Furin-like repeats
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.4.21.-
    KEGG - Orthology:
    K08671
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    SPC5; MGC34749; PC4; Proprotein convertase subtilisin/kexin type 4
    Approved Symbol:
    PCSK4
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 06773 Entrez Gene ID: 54760 OMIM ID: 600487 Swissprot Accession: Q6UW60; B3KQ28;