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Description for Protein CTSA

cathepsin A
5 total interacting proteins; 4 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 5/2)
(alpha granules: 1; platelet: 4; secretome: 2; undefined: 1)
Summary:
This gene encodes a glycoprotein which associates with lysosomal enzymes beta-galactosidase and neuraminidase to form a complex of high molecular weight multimers. The formation of this complex provides a protective role for stability and activity. Deficiencies in this gene are linked to multiple forms of galactosialidosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.4.16.5
    KEGG - Orthology:
    K13289
    KEGG - Pathway(s):
    hsa04142; hsa04614
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Protective protein/Cathepsin A; PPCA; Carboxypeptidase L; Carboxypeptidase C; Beta-galactosidase 2; GLB2; CTSA; Protective protein for beta galactosidase; EC 3.4.16.5
    Approved Symbol:
    CTSA
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Galactosialidosis(Pd);
  • Galactosialidosis, early infantile(Pd);
  • Galactosialidosis, late infantile(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 02020 Entrez Gene ID: 5476 OMIM ID: 613111 Swissprot Accession: P10619; B4E324;