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Description for Protein FBLIM1

filamin binding LIM protein 1
3 total interacting proteins; 3 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/2)
(platelet: 1; undefined: 1)
Summary:
This gene encodes a protein with an N-terminal filamin-binding domain, a central proline-rich domain, and, multiple C-terminal LIM domains. This protein localizes at cell junctions and may link cell adhesion structures to the actin cytoskeleton. This protein may be involved in the assembly and stabilization of actin-filaments and likely plays a role in modulating cell adhesion, cell morphology and cell motility. This protein also localizes to the nucleus and may affect cardiomyocyte differentiation after binding with the CSX/NKX2-5 transcription factor. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • NES: Nuclear Export Signal
  • LIM: Zinc-binding domain present in Lin-11, Isl-1, Mec-3.
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    None Available
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    CAL; Migfilin; CSX-associated LIM; Filamin-binding LIM protein-1 isoform b; Filamin-binding LIM protein-1 isoform c; Filamin-binding LIM protein-1 isoform a; MIG2 and filamin interacting protein; FBLP1; Q8WUP2; MIG2 interacting protein; Mitogen inducible 2 interacting protein
    Approved Symbol:
    FBLIM1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 09669 Entrez Gene ID: 54751 OMIM ID: 607747 Swissprot Accession: Q8WUP2;