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Description for Protein PPEF1

protein phosphatase, EF-hand calcium binding domain 1
3 total interacting proteins; 3 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a member of the serine/threonine protein phosphatase with EF-hand motif family. The protein contains a protein phosphatase catalytic domain, and at least two EF-hand calcium-binding motifs in its C terminus. Although its substrate(s) is unknown, the encoded protein has been suggested to play a role in specific sensory neuron function and/or development. This gene shares high sequence similarity with the Drosophila retinal degeneration C (rdgC) gene. Several alternatively spliced transcript variants, each encoding a distinct isoform, have been described. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • PP2A: Protein phosphatase 2A homologues, catalytic domain.
  • IQ: Short calmodulin-binding motif containing conserved Ile and Gln residues.
  • EF: EF-hand, calcium binding motif
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.1.3.16
    KEGG - Orthology:
    K01090
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Protein phosphatase, EF-hand calcium-binding domain 1; Protein phosphatase with EF calcium-binding domain; PPEF; Serine/threonine protein phosphatase 7; PP7; PPP7C; Serine/threonine protein phosphatase with EF-hand motifs 1 isoform 1b; Serine/threonine protein phosphatase with EF-hand motifs 1 isoform 3; Serine/threonine protein phosphatase with EF-hand motifs 1 isoform 1
    Approved Symbol:
    PPEF1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 1
    Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 5 : 0
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 02118 Entrez Gene ID: 5475 OMIM ID: 300109 Swissprot Accession: O14829;