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Description for Protein PPBP

pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
13 total interacting proteins; 7 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 11/3)
(alpha granules: 1; membrane: 1; microparticles: 1; platelet: 7; secretome: 2; undefined: 2)
Summary:
The protein encoded by this gene is a platelet-derived growth factor that belongs to the CXC chemokine family. This growth factor is a potent chemoattractant and activator of neutrophils. It has been shown to stimulate various cellular processes including DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by synovial cells. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • SCY: Intercrine alpha family (small cytokine C-X-C) (chemokine CXC).
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K10029
    KEGG - Pathway(s):
    hsa04060; hsa04062
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Pro platelet basic protein; Thrombocidin 1; Thrombocidin 2; CXC chemokine ligand 7; CTAPIII; Thromboglobulin beta 1; Small inducible cytokine B7; Low affinity platelet factor IV; Neutrophil activating peptide 2; Connective tissue activating peptide III; Small inducible cytokine subfamily B, member 7; Platelet basic protein; SCYB7; PBP; CTAP3; TGB; TGB1; TC1; TC2; NAP2; LDGF; MDGF; THBGB; LA-PF4; THBGB1; Beta-TG; NAP-2-L1; CXCL7
    Approved Symbol:
    PPBP
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Ethanesulfonic Acid(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 07171 Entrez Gene ID: 5473 OMIM ID: 121010 Swissprot Accession: P02775;