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Description for Protein MARCH5

membrane-associated ring finger (C3HC4) 5
9 total interacting proteins; 4 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
MARCH5 is a ubiquitin ligase of the mitochondrial outer membrane that plays a role in the control of mitochondrial morphology by regulating mitofusin-2 (MFN2; MIM 608507) and DRP1 (DNM1L; MIM 603850) (Nakamura et al., 2006 [PubMed 16936636]).[supplied by OMIM] (PubMed Links)
Domains and Motifs:
  • PHD: PHD zinc finger
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    6.3.2.19
    KEGG - Orthology:
    K10660
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    MITOL; FLJ20445; RNF153; MARCH-V; Ring finger protein 153; Membrane-associated RING-CH protein V; Membrane-associated RING finger protein 5; E3 ubiquitin-protein ligase MARCH5
    Approved Symbol:
    MARCH5
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 4
    • Additional Identifiers:

    HPRD: 07909 Entrez Gene ID: 54708 OMIM ID: 610637 Swissprot Accession: Q9NX47;