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Description for Protein PDP1

pyruvate dehyrogenase phosphatase catalytic subunit 1
2 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(platelet: 2)
Summary:
Pyruvate dehydrogenase (E1) is one of the three components (E1, E2, and E3) of the large pyruvate dehydrogenase complex. Pyruvate dehydrogenase kinases catalyze phosphorylation of serine residues of E1 to inactivate the E1 component and inhibit the complex. Pyruvate dehydrogenase phosphatases catalyze the dephosphorylation and activation of the E1 component to reverse the effects of pyruvate dehydrogenase kinases. Pyruvate dehydrogenase phosphatase is a heterodimer consisting of catalytic and regulatory subunits. Two catalytic subunits have been reported; one is predominantly expressed in skeletal muscle and another one is is much more abundant in the liver. The catalytic subunit, encoded by this gene, is the former, and belongs to the protein phosphatase 2C (PP2C) superfamily. Along with the pyruvate dehydrogenase complex and pyruvate dehydrogenase kinases, this enzyme is located in the mitochondrial matrix. Mutation in this gene causes pyruvate dehydrogenase phosphatase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • PP2C: Serine/threonine phosphatases, family 2C, catalytic domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.1.3.43
    KEGG - Orthology:
    K01102
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Protein phosphatase 2C, magnesium dependent, catalytic subunit; PDP1; Pyruvate dehydrogenase phosphatase, catalytics subunit; PDPC; PDH; PDP; EC 3.1.3.43; Pyruvate dehydrogenase [Lipoamide] phosphatase 1, mitochondrial; Pyruvate dehydrogenase phosphatase, catalytic subunit 1; PDPC 1
    Approved Symbol:
    PDP1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 1
    Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Pyruvate dehydrogenase phosphatase deficiency(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 16185 Entrez Gene ID: 54704 OMIM ID: 605993 Swissprot Accession: Q9P0J1; Q6P1N1; B4DYX8;