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Description for Protein P4HTM

prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
1 total interacting proteins;
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The product of this gene belongs to the family of prolyl 4-hydroxylases. This protein is a prolyl hydroxylase that may be involved in the degradation of hypoxia-inducible transcription factors under normoxia. It plays a role in adaptation to hypoxia and may be related to cellular oxygen sensing. Alternatively spliced variants encoding different isoforms have been identified. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • P4HC: Prolyl 4-hydroxylase alpha subunit homologues.
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    1.14.11.-
    KEGG - Orthology:
    K06711
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    EC 1.14.11; PH 4; FLJ20262; Proline 4 hydroxylase; Hypoxia-inducible factor prolyl 4-hydroxylase isoform c; Hypoxia-inducible factor prolyl 4-hydroxylase isoform b; Hypoxia-inducible factor prolyl 4-hydroxylase isoform a
    Approved Symbol:
    P4HTM
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Vitamin C(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 3 : 1
  • Isoform 2 : 1
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 17842 Entrez Gene ID: 54681 OMIM ID: - Swissprot Accession: Q9NXG6;