Summary:
This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq] (PubMed Links)
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| Domains and Motifs:
ZnF_C4: c4 zinc finger in nuclear hormone receptors
HOLI: Ligand binding domain of hormone receptors
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Gene Ontology:
KEGG - Enzyme ID(s):
KEGG - Orthology:
K08530
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Nomenclature / Alternative Names:
PPARG1; PPARG2; PPARG3; PAX8/PPARG fusion gene; NR1C3; HUMPPARG; PPAR gamma; PPAR gamma2; Peroxisome proliferative activated receptor gamma isoform 2; Peroxisome proliferative activated receptor gamma isoform 1
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Approved Symbol:
| (De-) Phosphorylations:
Phosphorylation Targets:
| Total phosphorylation targets: 0 |
| Human phosphorylation targets: 0; | Predicted platelet targets: 0 |
| Protein Characteristics:
|  Associated Drugs (DrugBank Accession):
(2S)-2-(4-chlorophenoxy)-3-phenylpropanoic acid(db);
(2S)-2-(4-ethylphenoxy)-3-phenylpropanoic acid(db);
(2S)-2-(biphenyl-4-yloxy)-3-phenylpropanoic acid(db);
(2S)-2-ETHOXY-3-[4-(2-{4-[(METHYLSULFONYL)OXY]PHENYL}ETHOXY)PHENYL]PROPANOIC ACID(db);
(2S)-2-ETHOXY-3-{4-[2-(10H-PHENOXAZIN-10-YL)ETHOXY]PHENYL}PROPANOIC ACID(db);
(2S)-2-methoxy-3-{4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]-1-benzothiophen-7-yl}propanoic acid(db);
(2S)-3-(1-{[2-(2-CHLOROPHENYL)-5-METHYL-1,3-OXAZOL-4-YL]METHYL}-1H-INDOL-5-YL)-2-ETHOXYPROPANOIC ACID(db);
(4S,5E,7Z,10Z,13Z,16Z,19Z)-4-hydroxydocosa-5,7,10,13,16,19-hexaenoic acid(db);
(5E,14E)-11-oxoprosta-5,9,12,14-tetraen-1-oic acid(db);
(5R,6E,8Z,11Z,14Z,17Z)-5-hydroxyicosa-6,8,11,14,17-pentaenoic acid(db);
(8E,10S,12Z)-10-hydroxy-6-oxooctadeca-8,12-dienoic acid(db);
(8R,9Z,12Z)-8-hydroxy-6-oxooctadeca-9,12-dienoic acid(db);
(9S,10E,12Z)-9-hydroxyoctadeca-10,12-dienoic acid(db);
(9Z,11E,13S)-13-hydroxyoctadeca-9,11-dienoic acid(db);
(S)-3-(4-(2-Carbazol-9-Yl-Ethoxy)-Phenyl)-2-Ethoxy-Propionic Acid(db);
2-chloro-5-nitro-N-phenylbenzamide(db);
2-[(2,4-DICHLOROBENZOYL)AMINO]-5-(PYRIMIDIN-2-YLOXY)BENZOIC ACID(db);
2-{5-[3-(6-BENZOYL-1-PROPYLNAPHTHALEN-2-YLOXY)PROPOXY]INDOL-1-YL}ETHANOIC ACID(db);
2-{5-[3-(7-PROPYL-3-TRIFLUOROMETHYLBENZO[D]ISOXAZOL-6-YLOXY)PROPOXY]INDOL-1-YL}ETHANOIC ACID(db);
3-(5-methoxy-1H-indol-3-yl)propanoic acid(db);
3-FLUORO-N-[1-(4-FLUOROPHENYL)-3-(2-THIENYL)-1H-PYRAZOL-5-YL]BENZENESULFONAMIDE(db);
3-[5-(2-nitropent-1-en-1-yl)furan-2-yl]benzoic acid(db);
3-{5-methoxy-1-[(4-methoxyphenyl)sulfonyl]-1H-indol-3-yl}propanoic acid(db);
Balsalazide(db);
Bezafibrate(db);
difluoro(5-{2-[(5-octyl-1H-pyrrol-2-yl-kappaN)methylidene]-2H-pyrrol-5-yl-kappaN}pentanoato)boron(db);
Glipizide(db);
Icosapent(db);
Indomethacin(db);
Mesalazine(db);
Mitiglinide(db);
Nateglinide(db);
Pioglitazone(db);
Repaglinide(db);
Rosiglitazone(db);
Sulfasalazine(db);
Telmisartan(db);
Troglitazone(db)
Associated Genetic Diseases:
Colon cancer, somatic(Pd); Diabetes mellitus, type II, modifier of(Pd); Glioblastoma, susceptibility to(Pd); Insulin resistance, digenic(Pd); Lipodystrophy, familial partial, type 3(Pd); Obesity, severe(Pd); Pparg polymorphism c/t(Pd)
| Predicted Transmembrane Domains:
Isoform 4 : 0
Isoform 3 : 0
Isoform 2 : 0
Isoform 1 : 0
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