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Description for Protein UGT1A6

UDP glucuronosyltransferase 1 family, polypeptide A6
No Interacting Proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(secretome: 1)
Summary:
This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene is active on phenolic and planar compounds. Alternative splicing in the unique 5' end of this gene results in two transcript variants. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.4.1.17
    KEGG - Orthology:
    K00699
    KEGG - Pathway(s):
    hsa00040; hsa00053; hsa00140; hsa00500; hsa00830; hsa00860; hsa00980; hsa00982; hsa00983; hsa01100
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    UGT1F; GNT1; UDP glucuronosyltransferase 1A6; UDPGT; UGT1*6; UGT1-06; UGT1.6; Phenol metabolizing UDP glucuronosyltransferase; UDP glucuronosyltransferase 1-6 precursor microsomal; UGT1; UDP glycosyltransferase 1 family polypeptide A6 isoform 1 precursor; UDP glycosyltransferase 1 family polypeptide A6 isoform 2; HLUGP; HLUGP1; MGC29860; UDP glucuronosyltransferase 1 family polypeptide A6; EC 2.4.1.17
    Approved Symbol:
    UGT1A6
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 1
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 07071 Entrez Gene ID: 54578 OMIM ID: 606431 Swissprot Accession: P19224; Q5DT01; Q5DSZ8;