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Description for Protein XRN1

5'-3' exoribonuclease 1
31 total interacting proteins; 15 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
SEP1 localizes to cytoplasmic foci containing a complex of mRNA-degrading enzymes. In addition to mRNA metabolism, yeast Sep1 has been implicated in a variety of nuclear and cytoplasmic functions, including homologous recombination, meiosis, telomere maintenance, and microtubule assembly.[supplied by OMIM] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
3.1.13.-
KEGG - Orthology:
K12618
KEGG - Pathway(s):
hsa03018
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
SEP1; DKFZp434P0721; Strand exchange protein 1; DNA Strand exchange protein SEP1; 5`-3` exoribonuclease 1; 5`-3` exoribonuclease 1 isoform b
Approved Symbol:
XRN1
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 12
Human (de-) phosphorylation sites: 12; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

None Available

Associated Genetic Diseases:

None Available
Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 10470 Entrez Gene ID: 54464 OMIM ID: 607994 Swissprot Accession: Q8IZH2;