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Description for Protein PON2

paraoxonase 2
2 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 2/0)
(membrane: 1; platelet: 3)
Summary:
This gene encodes a member of the paraoxonase gene family, which includes three known members located adjacent to each other on the long arm of chromosome 7. The encoded protein is ubiquitously expressed in human tissues, membrane-bound, and may act as a cellular antioxidant, protecting cells from oxidative stress. Hydrolytic activity against acylhomoserine lactones, important bacterial quorum-sensing mediators, suggests the encoded protein may also play a role in defense responses to pathogenic bacteria. Mutations in this gene may be associated with vascular disease and a number of quantitative phenotypes related to diabetes. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.1.1.2; 3.1.8.1
    KEGG - Orthology:
    K01045
    K01140
    KEGG - Pathway(s):
    hsa01100
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Serum paraoxonase/arylesterase 2; Serum aryldialkylphosphatase 2; A esterase 2; Aromatic esterase 2; EC 3.1.1.2; EC 3.1.8.1; Paraoxonase 2 isoform 1; Paraoxonase 2 isoform 2
    Approved Symbol:
    PON2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Paraoxonase 2 polymorphism(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 03903 Entrez Gene ID: 5445 OMIM ID: 602447 Swissprot Accession: Q15165; A4D1H7;