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Description for Protein PON1

paraoxonase 1
3 total interacting proteins; 3 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 2/0)
(platelet: 1; secretome: 1)
Summary:
The enzyme encoded by this gene is an arylesterase that mainly hydrolyzes paroxon to produce p-nitrophenol. Paroxon is an organophosphorus anticholinesterase compound that is produced in vivo by oxidation of the insecticide parathion. Polymorphisms in this gene are a risk factor in coronary artery disease. The gene is found in a cluster of three related paraoxonase genes at 7q21.3. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.1.1.2; 3.1.8.1
    KEGG - Orthology:
    K01045
    K01140
    KEGG - Pathway(s):
    hsa01100
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    PON; Paroxonase, plasma; Arylesterase; Esterase A; ESA
    Approved Symbol:
    PON1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Cefazolin(db)

    Associated Genetic Diseases:

  • Coronary artery disease, susceptibility to(Pd);
  • Paraoxonase activity, elevated(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01351 Entrez Gene ID: 5444 OMIM ID: 168820 Swissprot Accession: P27169;