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Description for Protein POLR2I

polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
7 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit, in combination with two other polymerase subunits, forms the DNA binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA. The product of this gene has two zinc finger motifs with conserved cysteines and the subunit does possess zinc binding activity. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • ZnF_C2C2: C2C2 Zinc finger
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K03017
    KEGG - Pathway(s):
    hsa00230; hsa00240; hsa01100; hsa03020; hsa05016
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    RPB9; RNA polymerase II 14.5-KD subunit; hRPB14.5; DNA directed RNA polymerase II polypeptide I; Polymerase RNA II DNA directed polypeptide I 14.5kD; EC 2.7.7.6; RPB14.5
    Approved Symbol:
    POLR2I
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 5
    Human (de-) phosphorylation sites: 5; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 15944 Entrez Gene ID: 5438 OMIM ID: 180662 Swissprot Accession: P36954;