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Description for Protein POLR2E

polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
33 total interacting proteins; 8 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes the fifth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit is shared by the other two DNA-directed RNA polymerases and is present in two-fold molar excess over the other polymerase subunits. An interaction between this subunit and a hepatitis virus transactivating protein has been demonstrated, suggesting that interaction between transcriptional activators and the polymerase can occur through this subunit. A pseudogene is located on chromosome 11. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
None Available
KEGG - Orthology:
K03013
KEGG - Pathway(s):
hsa00230; hsa00240; hsa01100; hsa03020; hsa05016
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
Polymerase II, RNA, subunit E; RPB5; XAP4; RPABC1; hRPB25; hsRPB5; DNA directed RNA polymerase II 23 kDa polypeptide; EC 2.7.7.6; RPB25
Approved Symbol:
POLR2E
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 2
Human (de-) phosphorylation sites: 2; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

None Available

Associated Genetic Diseases:

None Available
Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 15946 Entrez Gene ID: 5434 OMIM ID: 180664 Swissprot Accession: P19388;