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Description for Protein POLR2C

polymerase (RNA) II (DNA directed) polypeptide C, 33kDa
31 total interacting proteins; 5 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes the third largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains a cysteine rich region and exists as a heterodimer with another polymerase subunit, POLR2J. These two subunits form a core subassembly unit of the polymerase. A pseudogene has been identified on chromosome 21. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • RPOLD: RNA polymerases D
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K03011
    KEGG - Pathway(s):
    hsa00230; hsa00240; hsa01100; hsa03020; hsa05016
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    RPB3; RPB31; hRPB33; hsRPB3; Polymerase II, RNA, subunit C; RPB33; DNA directed RNA polymerase II 33 kDa polypeptide; EC 2.7.7.6; Polymerase (RNA) II (DNA directed) polypeptide C, 33kDa; DNA directed RNA polymerase II polypeptide C
    Approved Symbol:
    POLR2C
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 2
    Human (de-) phosphorylation sites: 2; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 15945 Entrez Gene ID: 5432 OMIM ID: 180663 Swissprot Accession: P19387; Q6FGR6;