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Description for Protein POLR2B

polymerase (RNA) II (DNA directed) polypeptide B, 140kDa
32 total interacting proteins; 7 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes the second largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit, in combination with at least two other polymerase subunits, forms a structure within the polymerase that maintains contact in the active site of the enzyme between the DNA template and the newly synthesized RNA. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
2.7.7.6
KEGG - Orthology:
K03010
KEGG - Pathway(s):
hsa00230; hsa00240; hsa01100; hsa03020; hsa05016
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
RPB2; hsRPB2; hRPB140; RNA polymerase II, 140-kd subunit; RNA polymerase II, second largest subunit; DNA-directed RNA polymerase II 140 kDa polypeptide; EC 2.7.7.6; Polymerase II, RNA, subunit B
Approved Symbol:
POLR2B
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 8
Human (de-) phosphorylation sites: 8; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

None Available

Associated Genetic Diseases:

None Available
Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 15943 Entrez Gene ID: 5431 OMIM ID: 180661 Swissprot Accession: P30876;