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Description for Protein POLR2A

polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
133 total interacting proteins; 40 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(platelet: 1)
Summary:
This gene encodes the largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains a carboxy terminal domain composed of heptapeptide repeats that are essential for polymerase activity. These repeats contain serine and threonine residues that are phosphorylated in actively transcribing RNA polymerase. In addition, this subunit, in combination with several other polymerase subunits, forms the DNA binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • CC: Coiled Coil
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.7.6
    KEGG - Orthology:
    K03006
    KEGG - Pathway(s):
    hsa00230; hsa00240; hsa01100; hsa03020; hsa05016
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Polymerase II, RNA, subunit A; RNA polymerase II; Polymerase (RNA) II (DNA directed) polypeptide A, 220kDa; DNA-directed RNA polymerase II largest subunit; Alpha-amanitin resistance; POLRA; RPB1; RPBh1; hRPB220; RpIILS; RPO2; RPOL2; POLR2; hsRPB1; MGC75453; DNA directed RNA polymerase II polypeptide A; RNA POLYMERASE II, 220-KD SUBUNIT
    Approved Symbol:
    POLR2A
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 64
    Human (de-) phosphorylation sites: 64; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 08916 Entrez Gene ID: 5430 OMIM ID: 180660 Swissprot Accession: P24928;