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Description for Protein POLD1

polymerase (DNA directed), delta 1, catalytic subunit 125kDa
11 total interacting proteins; 3 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The DNA polymerase delta complex is involved in DNA replication and repair, and it consists of the proliferating cell nuclear antigen (PCNA; MIM 176740), the multisubunit replication factor C (see MIM 102579), and the 4 subunit polymerase complex: POLD1, POLD2 (MIM 600815), POLD3 (MIM 611415), and POLD4 (MIM 611525) (Liu and Warbrick, 2006 [PubMed 16934752]).[supplied by OMIM] (PubMed Links)
Domains and Motifs:
  • CC: Coiled Coil
  • NLS: Nuclear localization signal
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.7.7
    KEGG - Orthology:
    K02327
    KEGG - Pathway(s):
    hsa00230; hsa00240; hsa01100; hsa03030; hsa03410; hsa03420; hsa03430; hsa03440
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    DNA polymerase delta subunit p125; DNA polymerase delta catalytic subunit; POLD; Polymerase, DNA, delta-1, catalytic subunit; Polymerase DNA delta
    Approved Symbol:
    POLD1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 5
    Human (de-) phosphorylation sites: 5; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 08882 Entrez Gene ID: 5424 OMIM ID: 174761 Swissprot Accession: P28340;