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Description for Protein POLA1

polymerase (DNA directed), alpha 1, catalytic subunit
16 total interacting proteins; 9 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes the catalytic subunit of DNA polymerase, which together with a regulatory and two primase subunits, forms the DNA polymerase alpha complex. The catalytic subunit plays an essential role in the initiation of DNA replication. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
2.7.7.7
KEGG - Orthology:
K02320
KEGG - Pathway(s):
hsa00230; hsa00240; hsa01100; hsa03030
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
Polymerase, DNA directed, alpha 70kD; DNA polymerase alpha catalytic subunit
Approved Symbol:
POLA1
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 9
Human (de-) phosphorylation sites: 9; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • Cladribine(db);
  • Clofarabine(db);
  • Fludarabine(db);
  • Nelarabine(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 02416 Entrez Gene ID: 5422 OMIM ID: 312040 Swissprot Accession: P09884;