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Description for Protein NANS

N-acetylneuraminic acid synthase
1 total interacting proteins;
Icon Book Platelet Evidence (proteome studies/others : 2/1)
(platelet: 5; secretome: 1)
Summary:
This gene encodes an enzyme that functions in the biosynthetic pathways of sialic acids. In vitro, the encoded protein uses N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN), respectively; however, it exhibits much higher activity toward the Neu5Ac phosphate product. In insect cells, expression of this gene results in Neu5Ac and KDN production. This gene is related to the E. coli sialic acid synthase gene neuB, and it can partially restore sialic acid synthase activity in an E. coli neuB-negative mutant. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
2.5.1.56; 2.5.1.57
KEGG - Orthology:
K05304
KEGG - Pathway(s):
hsa00520; hsa01100
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
Sialic acid synthase; N-acetylneuraminate synthase; N-acetylneuraminic acid synthase; N-acetylneuraminate-9-phosphate synthase; SAS
Approved Symbol:
NANS
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 4
Human (de-) phosphorylation sites: 4; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

None Available

Associated Genetic Diseases:

None Available
Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 07285 Entrez Gene ID: 54187 OMIM ID: 605202 Swissprot Accession: Q9NR45;