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Description for Protein POLE3

polymerase (DNA directed), epsilon 3 (p17 subunit)
7 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
POLE3 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.[supplied by OMIM] (PubMed Links)
Domains and Motifs:
  • CC: Coiled Coil
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.7.7
    KEGG - Orthology:
    K02326
    KEGG - Pathway(s):
    hsa00230; hsa00240; hsa01100; hsa03030; hsa03410; hsa03420
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Polymerase, DNA, epsilon, 17kd subunit; Chromatin accessibility complex, 17kd subunit; NFYB like protein 1; YBL1; Chromatin accessibility complex 17; HuCHRAC17; CHRAC17
    Approved Symbol:
    POLE3
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 4
    Human (de-) phosphorylation sites: 4; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Cladribine(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 06274 Entrez Gene ID: 54107 OMIM ID: 607267 Swissprot Accession: Q9NRF9;