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Description for Protein BRWD1

bromodomain and WD repeat domain containing 1
3 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(platelet: 1)
Summary:
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 2 bromodomains and multiple WD repeats, and the function of this protein is not known. This gene is located within the Down syndrome region-2 on chromosome 21. Alternative splicing of this gene generates 3 transcript variants diverging at the 3' ends. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • BROMO: bromo domain
  • WD40: WD40 repeats
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K11798
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    WD repeat protein 9; N143; FLJ11315; C21orf107; Transcriptional unit N143; Chromosome 21 open reading frame 107; cAMP response element binding and beta tranducin family like; Bromodomain and WD repeat domain containing 1 isoform A; Bromodomain and WD repeat domain containing 1 isoform B; Bromodomain and WD repeat domain containing 1 isoform C
    Approved Symbol:
    BRWD1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 33
    Human (de-) phosphorylation sites: 33; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 11683 Entrez Gene ID: 54014 OMIM ID: - Swissprot Accession: Q9NSI6; Q6P2D1;