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Description for Protein PML

promyelocytic leukemia
82 total interacting proteins; 27 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • BBOX: B-Box-type zinc finger
  • CC: Coiled Coil
  • LZ: Leucine Zipper
  • NLS: Nuclear localization signal
  • RING: Ring finger
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K10054
    KEGG - Pathway(s):
    hsa04120; hsa04144; hsa05200; hsa05221
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Promyelocytic leukemia protein isoform 1; Promyelocytic leukemia protein isoform 9; Promyelocytic leukemia protein isoform 2; Promyelocytic leukemia protein isoform 5; Promyelocytic leukemia protein isoform 7; Promyelocytic leukemia protein isoform 8; Promyelocytic leukemia protein isoform 10; Promyelocytic leukemia protein isoform 11; RNF71; PP8675; RING finger protein 71; Tripartite motif protein TRIM19 kappa; Tripartite motif protein TRIM19 zeta; Tripartite motif protein TRIM19 lambda; PML IVa; Tripartite motif protein TRIM19 beta; PML VI; Tripartite motif protein TRIM19 epsilon; Tripartite motif protein TRIM19 iota; PML VIb; Tripartite motif protein TRIM19 eta; Tripartite motif protein TRIM19 theta; PML VIIb; Probable transcription factor, PML; Tripartite motif protein 19; MYL; TRIM19; Promyelocytic leukemia protein
    Approved Symbol:
    PML
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 46
    Human (de-) phosphorylation sites: 46; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
    00023_11(0)
    00023_10(0)
  • Isoform 9 : 0
  • Isoform 8 : 0
  • Isoform 7 : 0
  • Isoform 6 : 0
  • Isoform 5 : 0
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00023 Entrez Gene ID: 5371 OMIM ID: 102578 Swissprot Accession: P29590; Q59FP9; Q9BZX7;