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Description for Protein PLOD1

procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1
1 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/1)
(membrane: 1; undefined: 1)
Summary:
Lysyl hydroxylase is a membrane-bound homodimeric protein localized to the cisternae of the endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VI have deficiencies in lysyl hydroxylase activity. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • P4HC: Prolyl 4-hydroxylase alpha subunit homologues.
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    1.14.11.4
    KEGG - Orthology:
    K00473
    KEGG - Pathway(s):
    hsa00310
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    PLOD; Procollagen lysine 2-oxoglutarate 5-dioxygenase; LLH; LH; Lysyl hydroxylase
    Approved Symbol:
    PLOD1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 3
    Human (de-) phosphorylation sites: 3; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Succinic acid(db);
  • Vitamin C(db)

    Associated Genetic Diseases:

  • Ehlers-Danlos syndrome, type VIA(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01086 Entrez Gene ID: 5351 OMIM ID: 153454 Swissprot Accession: Q02809;