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Description for Protein PLG

plasminogen
50 total interacting proteins; 25 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 6/0)
(alpha granules: 1; membrane: 1; microparticles: 1; platelet: 2; secretome: 1)
Summary:
The protein encoded by this gene is a secreted blood zymogen that is activated by proteolysis and converted to plasmin and angiostatin. Plasmin dissolves fibrin in blood clots and is an important protease in many other cellular processes while angiostatin inhibits angiogenesis. Defects in this gene are likely a cause of thrombophilia and ligneous conjunctivitis. Two transcript variants encoding different isoforms have been found for this gene. (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • TRYPSIN: Trypsin-like serine protease
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.4.21.7
    KEGG - Orthology:
    K01315
    KEGG - Pathway(s):
    hsa04080; hsa04610
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Microplasmin; Angiostatin
    Approved Symbol:
    PLG
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 1
    Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Alteplase(db);
  • Aminocaproic Acid(db);
  • Anistreplase(db);
  • Aprotinin(db);
  • Bicine(db);
  • Reteplase(db);
  • Streptokinase(db);
  • Tenecteplase(db);
  • Tranexamic Acid(db);
  • Urokinase(db)

    Associated Genetic Diseases:

  • Conjunctivitis, Ligneous(Pd);
  • Plasminogen Kanagawa-I(Pd);
  • Thrombophilia due to plasminogen deficiency(Pd);
  • Thrombophilia due to plasminogen Nagoya I(Pd);
  • Thrombophilia due to plasminogen Tochigi(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01417 Entrez Gene ID: 5340 OMIM ID: 173350 Swissprot Accession: P00747; Q5TEH5;