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Description for Protein ATP6V1G2

ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2
1 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(platelet: 8)
Summary:
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular compartments of eukaryotic cells. V-ATPase dependent acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is one of three V1 domain G subunit proteins. This gene had previous gene symbols of ATP6G and ATP6G2. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • CC: Coiled Coil
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.6.3.14
    KEGG - Orthology:
    K02152
    KEGG - Pathway(s):
    hsa00190; hsa01100; hsa04966; hsa05110; hsa05120
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    ATPase H+ transporting lysosomal V1 subunit G2 isoform b; ATP6G2; Vacuolar ATP synthase subunit G2; V ATPase G subunit 2; Vacuolar proton pump G subunit 2; V ATPase 13 kDa subunit 2; ATP6G; EC 3.6.3.14; NG38; ATPase, H+ transporting, lysosomal, V1 subunit G2 isoform a
    Approved Symbol:
    ATP6V1G2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 06030 Entrez Gene ID: 534 OMIM ID: 606853 Swissprot Accession: O95670; B5MEF0; Q2L6F8;