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Description for Protein PLD1

phospholipase D1, phosphatidylcholine-specific
26 total interacting proteins; 23 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(undefined: 1)
Summary:
Phosphatidylcholine (PC)-specific phospholipases D (PLDs; EC 3.1.4.4) catalyze the hydrolysis of PC to produce phosphatidic acid and choline. A range of agonists acting through G protein-coupled receptors and receptor tyrosine kinases stimulate this hydrolysis. PC-specific PLD activity has been implicated in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis (Hammond et al., 1995 [PubMed 8530346]).[supplied by OMIM] (PubMed Links)
Domains and Motifs:
  • PH: Pleckstrin homology domain.
  • PX: PhoX homologous domain, present in p47phox and p40phox.
  • PLDc: Phospholipase D. Active site motifs.
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.1.4.4
    KEGG - Orthology:
    K01115
    KEGG - Pathway(s):
    hsa00564; hsa00565; hsa01100; hsa04144; hsa04666; hsa04912; hsa05200; hsa05212
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Phospholipase D1 phophatidylcholine specific; Phosphatidylcholine hydrolyzing phospholipase D1
    Approved Symbol:
    PLD1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 10
    Human (de-) phosphorylation sites: 10; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Choline(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 03855 Entrez Gene ID: 5337 OMIM ID: 602382 Swissprot Accession: Q59EA4; Q13393;