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Description for Protein PLCG2

phospholipase C, gamma 2 (phosphatidylinositol-specific)
35 total interacting proteins; 25 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 3/0)
(microparticles: 1; platelet: 2)
Summary:
Enzymes of the phospholipase C family catalyze the hydrolysis of phospholipids to yield diacylglycerols and water-soluble phosphorylated derivatives of the lipid head groups. A number of these enzymes have specificity for phosphoinositides. Of the phosphoinositide-specific phospholipase C enzymes, C-beta is regulated by heterotrimeric G protein-coupled receptors, while the closely related C-gamma-1 (PLCG1; MIM 172420) and C-gamma-2 enzymes are controlled by receptor tyrosine kinases. The C-gamma-1 and C-gamma-2 enzymes are composed of phospholipase domains that flank regions of homology to noncatalytic domains of the SRC oncogene product, SH2 and SH3.[supplied by OMIM] (PubMed Links)
Domains and Motifs:
  • C2: Protein kinase C conserved region 2 (CalB)
  • PH: Pleckstrin homology domain.
  • PLCXc: Phospholipase C, catalytic domain (part)
  • domain X
  • SH2: Src homology 2 domains
  • SH3: Src homology 3 domains
  • PLCYc: Phospholipase C, catalytic domain (part)
  • domain Y
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.1.4.11
    KEGG - Orthology:
    K05859
    KEGG - Pathway(s):
    hsa00562; hsa01100; hsa04012; hsa04020; hsa04070; hsa04370; hsa04650; hsa04662; hsa04664; hsa04666; hsa04670; hsa04722; hsa05110; hsa05120; hsa05200; hsa05214; hsa05223
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    PLC, phosphatidylinositol specific; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2; PLC 4; Phospholipase C, gamma 2; Phospholipase C, gamma 2 (phosphatidylinositol-specific); PLC-IV
    Approved Symbol:
    PLCG2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 16
    Human (de-) phosphorylation sites: 16; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 02570 Entrez Gene ID: 5336 OMIM ID: 600220 Swissprot Accession: P16885;