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Description for Protein PLCG1

phospholipase C, gamma 1
114 total interacting proteins; 70 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • C2: Protein kinase C conserved region 2 (CalB)
  • PH: Pleckstrin homology domain.
  • SH2: Src homology 2 domains
  • SH3: Src homology 3 domains
  • PLCXc: Phospholipase C, catalytic domain (part)
  • domain X
  • PLCYc: Phospholipase C, catalytic domain (part)
  • domain Y
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.1.4.11
    KEGG - Orthology:
    K05859
    KEGG - Pathway(s):
    hsa00562; hsa01100; hsa04012; hsa04020; hsa04070; hsa04370; hsa04650; hsa04660; hsa04664; hsa04666; hsa04670; hsa04722; hsa05110; hsa05120; hsa05200; hsa05214; hsa05223
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    PLC, gamma 1; PLC1; Phospholipase C gamma 1 isoform b; Phospholipase C gamma 1 isoform a; PLC148
    Approved Symbol:
    PLCG1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 22
    Human (de-) phosphorylation sites: 22; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01398 Entrez Gene ID: 5335 OMIM ID: 172420 Swissprot Accession: Q4LE43; A2A284; P19174;