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Description for Protein BCL11A

B-cell CLL/lymphoma 11A (zinc finger protein)
2 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a/Evi9 protein. The corresponding mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with BCL6. During hematopoietic cell differentiation, this gene is down-regulated. It is possibly involved in lymphoma pathogenesis since translocations associated with B-cell malignancies also deregulates its expression. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • ZNFC2: zinc finger
  • CC: Coiled Coil
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    None Available
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    B cell CLL/lymphoma 11A; CTIP1 protein; CTIP1; EVI9; B cell lymphoma/leukaemia 11A; FLJ10173; KIAA1809; BCL11A-XL; C2H2-type zinc finger protein; Ecotropic viral integration site 9; Ecotropic viral integration site 9 homolog; BCL11A-L; COUP-TF interacting protein 1; BCL11AXL; Evi9a; BCL11A-S; B-cell CLL/lymphoma 11A isoform 1; B-cell CLL/lymphoma 11A isoform 2; B-cell CLL/lymphoma 11A isoform 5; B-cell CLL/lymphoma 11A isoform 3
    Approved Symbol:
    BCL11A
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 16
    Human (de-) phosphorylation sites: 16; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 05949 Entrez Gene ID: 53335 OMIM ID: 606557 Swissprot Accession: Q9H165;